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10.1080/17512433.2016.1245142
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Early drug development: assessment of proarrhythmic risk and cardiovascular safety
Robert M. Lester
Joy Olbertz
Taylor & Francis
Expert Review of Clinical Pharmacology, 2016. doi:10.1080/17512433.2016.1245142
Thorough QT
ICH E14
ICH S7B
hERG
Torsades de pointes
QT interval
proarrhythmia
exposure response modelling
comprehensive in vitro proarrhythmia assay
cardiovascular safety
Journal
Expert Review of Clinical Pharmacology
© 2016 Informa UK Limited, trading as Taylor & Francis Group
1751-2433
1751-2441
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10.1080/17512433.2016.1245142
http://dx.doi.org/10.1080/17512433.2016.1245142
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Thorough QT; ICH E14; ICH S7B; hERG; Torsades de pointes; QT interval; proarrhythmia; exposure response modelling; comprehensive in vitro proarrhythmia assay; cardiovascular safety
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