Neutralizing Antibody (NAb) Assays
Our scientific experts develop and validate phase appropriate NAb methods to meet regulatory expectations for your therapeutic program.
NAb assays are an important component of immunogenicity testing, and selecting the appropriate format is critical. At Celerion, we have the expertise to support you with:
- Competitive ligand binding methods
- Cell based methods
- Enzymatic methods
Competitive ligand binding (cLB) NAb Assay Services
At Celerion, we have extensive hands-on experience developing assays for antagonistic antibody therapeutics, including cLB NAb assays. Our scientific teams leverage our ELISA and ECL capabilities, including labeling and characterizing custom reagents, to ensure robust, sensitive cLB methods are in place for NAb sample testing.
Cell-based NAb Assay Services
Our specialized cell-based assay teams are well versed in the unique challenges that come with these high complexity methods, enabling us to take a strategic approach to assay design to maximize drug tolerance and sensitivity. We utilize trusted vendors for sourcing and screening appropriate cell lines and produce high-quality cell banks in house.
Enzymatic NAb Assay Services
Biologics that function through catalytic or enzymatic activity often require a unique, customized design for NAb testing. Partner with a CRO that understands how to best leverage enzymatic methods to create the appropriate solution for your immunogenicity testing strategy.
