Small Molecule Expertise


Analysis of small molecule drugs, and metabolites including peptides and oligonucleotides

Key Strategies for Small Molecule Bioanalysis

However complex your bioanalytical challenge, we will help you achieve an excellent study outcome. We have the most comprehensive list of assays in the industry, with over 500 off the shelf assays to support small molecule bioanalysis.

Our experience and expertise in traditional small molecule, metabolite, including peptide and oligonucleotide bioanalysis. Plus, we have the capacity to meet your study timelines. Our established laboratories are located in Lincoln, Nebraska and Zurich, Switzerland.

Celerion’s highly-qualified scientists have on average more than 10 years of industry experience developing bioanalytical methods to support small molecule bioanalysis. We provide full GLP-compliant services in method validation and sample analysis for traditional small molecules, metabolites, therapeutic proteins, biomarkers, antibodies, nucleic acids, and peptides. The team offers expertise in the LC-MS/MS analysis of endogenous biomarkers, their congeners and metabolites such as leukotrienes, prostaglandins, peptides, steroids and other compounds.

Our method development capabilities include sensitive and reliable bioanalytical methods for generics and New Molecular Entities (NME). We have overcome challenging methods, such as those requiring drug derivatization, chiral separation, drug stabilization, and multiple metabolite quantitation.

We use the most advanced technologies and strategies to ensure on-time delivery of high-quality data. Small molecule work is performed using LC-MS/MS with HPLC, UPLC, 2D-chromatography or MicroLC techniques. We also utilize state-of-the-art automation technologies such as Caliper Sciclone, Hamilton, Tecan to automate sample analysis processes and deliver data to you quickly and efficiently. With over 42 LC-MS/MS instruments available for method development, validation and sample analysis, Celerion has the capacity and expertise to meet and exceed your study timelines.

 

Application of 2D-Chromatography

The Development of a method for the Determination of Cortisol and 6-Beta-Hydroxycortisol in Human Urine Using 2D-Chromatography

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